The pick six paid $432,286 on Wednesday to one winning ticketholder.
The bet began with a carryover of $91,748 from Sunday in the main pool and $40,149 in the single ticket jackpot pool.
The winners of Wednesday's pick six races were Hartel ($5.60), Snaked ($7.80), Marjorie E ($9), Lakerball ($7.60), Divisor ($12.80), and Pacific Song ($40.60).
Hartel was the only winning favorite. Consolation tickets with five winners were worth $477. The winning ticket was purchased for $432 through Twin Spires.